PRAZOSIN
THERAPEUTICS
Class
- Alpha 1 adrenergic blocker
PRAZOSIN commonly prescribed for
(Bold for FDA approved)
• Nightmares associated with posttraumatic stress disorder (PTSD)
• Blood circulation disorders
• Problems urinating due to enlarged prostate
• Passing of kidney stones
How PRAZOSIN works
• Blocks alpha 1 adrenergic receptors to reduce noradrenergic hyperactivation
• Stimulation of central noradrenergic receptors during sleep may activate traumatic memories, so blocking this activation may reduce nightmares
How long until PRAZOSIN works
• Within a few days to a few weeks
SIDE EFFECTS
Notable Side Effects
• Dizziness, lightheadedness, headache, fatigue, blurred vision
• Nausea
Life Threatening Side Effects
• Syncope with sudden loss of consciousness
weight gain

unusual
sedation

not usual
What to do about PRAZOSIN side effects
• Lower the dose
• Wait
• Wait
• Wait
• In a few weeks, switch to another agent
DOSING AND USE
usual dosage range
• 1–16 mg/day, generally in divided doses
Dosage Forms
• Capsule 1 mg, 2 mg, 5 mg
long term use
• Has not been evaluated in controlled studies
• Nightmares may return if prazosin is stopped
habit forming
• No
SPECIAL POPULATIONS
Renal Impairment
• Use with caution in patients with severe impairment
• May require lower dose
Hepatic Impairment
• Use with caution
Cardiac Impairment
• Use with caution in patients who are predisposed to hypotensive or syncopal episodes
Elderly
• Some patients may tolerate lower doses better
• Higher risk of orthostatic hypotension and syncope
Children and Adolescents
• Safety and efficacy have not been established
Pregnancy
• Effective June 30, 2015, the FDA requires changes to the content and format of pregnancy and lactation information in prescription drug labels, including the elimination of the pregnancy letter categories; the Pregnancy and Lactation Labeling Rule (PLLR or final rule) applies only to prescription drugs and will be phased in gradually for drugs approved on or after June 30, 2001
• Controlled studies have not been conducted in pregnant women
• Prazosin has been used alone or in combination with other hypotensive agents in severe hypertension of pregnancy, with no fetal or neonatal abnormalities reported
• Prazosin should be used during pregnancy only if the potential benefits justify the potential risks to the mother and fetus
Breast Feeding
• Some drug is present in breast milk
• If child becomes irritable or sedated, breast feeding or drug may need to be discontinued
• Must weigh benefits of breast feeding with risks and benefits of treatment versus nontreatment to both the infant and the mother
Based on data Published online by Cambridge University Press
Compiled by Dr. Jash Ajmera