Class

• Medical food
• Cognitive enhancer

CAPRYLIDENE commonly prescribed for

(Bold for FDA approved)

How CAPRYLIDENE works

• Induces hyperketonemia and provides an alternative energy substrate to glucose in the brain

• Caprylidene is processed in the gut, resulting in medium-chain fatty acids that pass to the liver and undergo obligate oxidation, ultimately being formed into ketone bodies (acetoacetate and betahydroxybutyric acid)

• Ketone bodies cross the blood–brain barrier and are taken up by neurons and enter the mitochondria, where they increase mitochondrial efficiency

• Ketone bodies also generate ATP and increase pools of acetyl-CoA and acetylcholine

How long until CAPRYLIDENE works

• May begin working immediately

Notable Side Effects

• Diarrhea, flatulence, dyspepsia

• Nausea, headache

Life Threatening Side Effects

• None reported

weight gain

unusual

sedation

unusual

What to do about CAPRYLIDENE side effects

• Take it with food

• Sip it slowly over approximately 30 minutes

• Consider lowering the dose

usual dosage range

• 40 g/day

Dosage Forms

• Powder 40 g/packet

long term use

• Not studied

• Drug may lose effectiveness as the course of Alzheimer disease progresses

habit forming

• No

Renal Impairment

• Not studied

Hepatic Impairment

• Not studied

Cardiac Impairment

• Not studied

Elderly

• Dose adjustment not necessary

Children and Adolescents

• Safety and efficacy have not been established

Pregnancy

• Controlled studies have not been conducted in pregnant women

• Animal studies have not shown teratogenic effects

Breast Feeding

• Unknown if caprylidene is secreted in human breast milk